Graduate School of Dentistry

The Graduate School of Dentistry offers various postgraduate seminars and lectures.
Students have access to the facilities at the Institute of Dental Research.

Director�EYasuo Nishikawa

Director : Prof.
Yasuo Nishikawa


Basic Science

Anatomy

  • Systematic and comparative anatomy of the vascular system in micro and macro levels
  • Experimental study of wound healing mechanism
  • Observation of the bone and microvascular changes surrounding dental implants
  • Immunohistological study of the nervous system and the bone

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Oral Anatomy

  • Tooth morphology and comparative odontology
  • Morphological and functional analyses of dental arches
  • Embryology and histology of dental and periodontal tissues
  • Genesis and molecular biology of dental and periodontal tissues
  • Fine structure study of dental and periodontal tissues
  • Lymphatics in the oral tissues
  • The development of taste buds, function and sensation
  • Oral pain
  • Tissue engineering for generation of dental and periodontal tissues

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Physiology

  • Study of saliva and salivary gland
  • Relationship between xerostomia (dry mouth) and salivary gland dysfunction
  • Neural mechanism of maxillofacial pain
  • Role of natural killer cells for the prevention of periodontal disease

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Biochemistry

  • Mechanism of bone remodeling
    (interaction of osteoblast and osteoclast, intracellular signal transduction)
  • Mechanism of bone metabolism under inflammatory condition
    (influence of inflammatory cytokines)
  • Relationship between general diseases and alveolar bone metabolism
    (influences of adipokines, lipid-lowering drugs, remedy for osteoporosis)

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Oral Pathology

  • Promoting factors in periodontal tissue regeneration
  • Osteoblast differentiation and the change of alveolar bone
  • Relationship between dental implant body and peri-implant bone formation
  • Cell-cycle regulatory proteins in oral cancer and salivary gland tumor
  • Relationship between cell-cycle regulators and cell adhesion molecules in oral tumor
  • Relationship between oral disease and virus

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Bacteriology

  • Distribution of biofilm-forming bacteria in the oral cavity
  • Role of biofilm-forming bacteria in the development of oral persistent inflammatory diseases
  • Biofilm formation-gene expression relay system

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Pharmacology

  • Mechanism of inflammation and wound healing
  • Development of new dental drugs
  • Studies on leukocyte chemotaxis, phagocytosis, and active oxygen
  • Regenerative medicine
  • Etiology and pathology of periodontal disease
  • Influence of diabetes on periodontal disease
  • Differentiation of dental pulp stem cells
  • Stress markers in saliva
  • Genetic diagnosis of oral diseases

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Biomaterials

  • Biocompatibility of biomaterials
  • Study of the surface modification on titanium
  • Biological evaluation of biomaterials using embryonic stem (ES) cell
  • Study of metal allergy
  • Development of multifunctional denture liner
  • Development of bioabsorbable scaffolds with self-organization behavior
  • Analysis of bone formation on bovine periosteal cells

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Preventive and Community Dentistry

  • Early detection of dental caries
  • Effect of fluoride in dental caries prevention and oral health
  • Development of substitute material for fluoride
  • Development of remineralization-promoting agent
  • Risk factors of periodontal disease
  • Early detection of gingivitis
  • Gene analysis for tooth loss
  • Epidemiology of oral health
  • Development of oral health promotion system
  • Theory of oral health promotion
  • Oral age
  • e-oral health

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Clinical Dentistry

Operative Dentistry

  • Dental education in operative dentistry
  • Bonding to tooth substrate and various restoratives
  • Fundamental and clinical study of dental laser in operative dentistry
  • Fundamental and clinical study of tooth whitening
  • Dental ergonomics

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Endodontics

  • Identification and characterization of bacteria isolated from infected dental pulp and root canal in relation to clinical symptoms
  • Development and clinical application of anaerobic culture system
  • Evaluation of cytotoxicity and tissue injury on various agents for endodontic treatment
  • Tissue culture study on the significance of the storage media and the load used during tooth replantation
  • Effects of dental laser, oxidative potential water, and Ni-Ti rotary file in root canal treatment
  • Application of calcium phosphate to root canal sealers

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Periodontology

  • Mechanism of periodontal tissue regeneration
  • Histopathological study of enamel matrix derivative
  • Immunological study of host defense on periodontal epithelial cell
  • Relationship between diabetes and periodontal disease
  • Clinical study of foul breath to develop a new measure equipment
  • Clinical study of local drug delivery system

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Geriatric Dentistry

  • Study on prosthesis processing by laser, dental application of titanium, new ceramic materials, and denture base materials
  • Ultrastructural, histochemical, and biochemical study of the adaptability on prosthetic treatment and peripheral tissues
  • Movement analysis of jaw, muscle, and swallowing for the maintenance and the recovery of stomatognathic function in aged people
  • Stress analysis of the prosthetic treatment and three-dimensional measurements of craniofacial lesion in aged people
  • Clinical study of oral care and dry mouth in aged people

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Fixed Prosthodontics

  • Bio-measurement of stomatognathic system
  • Influence of occlusion and mastication to general health
  • Clinical test and diagnosis of disease and disorder on stomatognathic function
  • Clinical test of occlusal contact, masticatory muscle, temporomandibular joint, mandibular movement, and periodontal ligament
  • Measurement of dental implant stability
  • Dental shade measurement applying artificial vision technology

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Removable Prosthodontics

  • Biological observations of implant stability supported by osseointegration in the early stage of dental implantation
  • Influence of loss of posterior occlusal support and restored support by removable partial dentures on stress hormone in saliva
  • Retention mechanism and functional stress analyses of RPD
  • Analysis of motor evoked potentials in masseter muscles
  • Influence of occlusion or tooth loss on release of neurotransmitter in prefrontal cortex of rat using Microdialysis method

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Oral and Maxillofacial Surgery 1

  • Molecular pathology on carcinogenesis of oral precancerous lesions
  • Clinical pathology of oral tumors
  • Clinical study of temporomandibular joint disorders
  • Drug resistance on causative bacterial pathogen of odontogenic infection
  • Reconstruction of alveolar bone and jaw bone
  • Psychiatric approach of dry mouth

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Oral and Maxillofacial Surgery 2

  • Biological basis and clinical application of temporomandibular joint disorders
  • Stress factor of the patients with temporomandibular joint disorders
  • Development of the thin endoscope for temporomandibular joint
  • Study of cell invasion divided from oral cancer
  • Clinical study of oral cancer prognosis
  • Study on induction of cell differentiation divided from ameloblastoma
  • Study of dentofacial deformity
  • Clinical study on the surface properties of dental implants
  • Electrophysiology of sensory nerve regeneration
  • Study of salivary gland regeneration

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Orthodontics

  • Morphological changes on the palate of patients with cleft lip and cleft palate
  • Treatment effect of the palatal plate on cleft lip or cleft palate children
  • Relationship between craniofacial morphology and masticatory muscle of MRI morphology
  • Relationship between craniofacial morphology and bite force or mastication
  • Psychological characteristics on jaw deformity patients
  • Morphological evaluation of craniofacial soft tissue using frequency analysis
  • Evaluation of the tooth position changes before and after the virtual treatment on three-dimensional digital dental cast
  • Evaluation of craniofacial morphology by three-dimensional digital image
  • Analysis of stress distribution during tooth movement by three-dimensional finite element method
  • Differentiation and proliferation of osteoclasts
  • Development of materials as bone apposition in the orthodontic treatment

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Oral Radiology

  • Computer-aided image analysis of oral tumor based on statistical data
  • Observation of image changes on odontogenic infection
  • Causative study of temporomandibular joint disorders
  • Image analysis of salivary gland disease
  • Image analysis on dental implant
  • Effect of high-dose-rate interstitial brachytherapy for oral tongue cancer
  • Treatment results of radiotherapy for gingival cancer
  • Development of surface coil for MRI in dentistry
  • Clinical application of Cone-beam Computed Tomography for dentomaxillofacial region

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Pediatric Dentistry

  • Influence of cytokine secretion on fibroblast to blood cell differentiation and proliferation
  • Morphological changes on oral hard tissues of neonatal rats born to mothers given methamphetamine during pregnancy
  • Apoptosis induced by Streptococcus mutans on cultured human dental pulp cell
  • Aging changes of dental arch and jaw bone on occlusal growth and development in childhood
  • Characteristics of tooth trauma (fracture of jaw) on children
  • Measurement of psychiatric tension on children during dental care
  • Effect of rotational toothbrush on oral hygiene of children
  • Statistical classification of congenital deciduous and permanent teeth missing
  • Behavior modification on physically and mentally handicapped patients during dental care
  • Instruction of tooth brushing on autistic patients

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Oral Anesthesiology

  • Basic study on cerebral venous infarction in oral and maxillofacial surgery
  • Basic study of neuropathic pain
  • Pain stimulation of the trigeminal nerve and occlusal disorders in relation to monoamine metabolism
  • Basic study of upper airway reflexes
  • Medical law of medical malpractice in anesthesia
  • Clinical study of general anesthesia and sedation
  • Clinical study of dental pain clinic
  • Systemic management of medically compromised patients in dental care

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